Tomohisa Kuzuyama
Tomohisa Kuzuyama
The University of Tokyo, Department of Biotechnology
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A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis
S Takahashi, T Kuzuyama, H Watanabe, H Seto
Proceedings of the National Academy of Sciences 95 (17), 9879-9884, 1998
Minimum information about a biosynthetic gene cluster
MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ...
Nature chemical biology 11 (9), 625-631, 2015
Fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis
T Kuzuyama, T Shimizu, S Takahashi, H Seto
Tetrahedron letters 39 (43), 7913-7916, 1998
Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units
T Kuzuyama
Bioscience, biotechnology, and biochemistry 66 (8), 1619-1627, 2002
Terpene synthases are widely distributed in bacteria
Y Yamada, T Kuzuyama, M Komatsu, K Shin-Ya, S Omura, DE Cane, ...
Proceedings of the National Academy of Sciences 112 (3), 857-862, 2015
Diversity of the biosynthesis of the isoprene units
T Kuzuyama, H Seto
Natural product reports 20 (2), 171-183, 2003
Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products
T Kuzuyama, JP Noel, SB Richard
Nature 435 (7044), 983-987, 2005
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins inArabidopsis
H Kasahara, A Hanada, T Kuzuyama, M Takagi, Y Kamiya, S Yamaguchi
Journal of Biological Chemistry 277 (47), 45188-45194, 2002
Analysis of the expression of CLA1, a gene that encodes the 1-deoxyxylulose 5-phosphate synthase of the 2-C-methyl-D-erythritol-4-phosphate pathway in Arabidopsis
JM Estévez, A Cantero, C Romero, H Kawaide, LF Jiménez, T Kuzuyama, ...
Plant physiology 124 (1), 95-104, 2000
Bioactive natural products with carbon–phosphorus bonds and their biosynthesis
H Seto, T Kuzuyama
Natural product reports 16 (5), 589-596, 1999
An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190
K Kaneda, T Kuzuyama, M Takagi, Y Hayakawa, H Seto
Proceedings of the National Academy of Sciences 98 (3), 932-937, 2001
Direct formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose 5-phosphate by 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a new enzyme in the non …
T Kuzuyama, S Takahashi, H Watanabe, H Seto
Tetrahedron Letters 39 (25), 4509-4512, 1998
Cloning and Characterization of 1-Deoxy-d-Xylulose 5-Phosphate Synthase fromStreptomyces sp. Strain CL190, Which Uses both the Mevalonate and …
T Kuzuyama, M Takagi, S Takahashi, H Seto
Journal of bacteriology 182 (4), 891-897, 2000
Characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid …
T Kuzuyama, S Takahashi, M Takagi, H Seto
Journal of Biological Chemistry 275 (26), 19928-19932, 2000
Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol from 2-C-methyl-d-erythritol 4-phosphate by 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase, a new …
T Kuzuyama, M Takagi, K Kaneda, T Dairi, H Seto
Tetrahedron Letters 41 (5), 703-706, 2000
Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-D …
T Kuzuyama, M Takagi, K Kaneda, H Watanabe, T Dairi, H Seto
Tetrahedron Letters 41 (16), 2925-2928, 2000
The ABBA family of aromatic prenyltransferases: broadening natural product diversity
M Tello, T Kuzuyama, L Heide, JP Noel, SB Richard
Cellular and molecular life sciences: CMLS 65 (10), 1459, 2008
Studies on the nonmevalonate pathway: formation of 2-C-methyl-d-erythritol 2, 4-cyclodiphosphate from 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol
M Takagi, T Kuzuyama, K Kaneda, H Watanabe, T Dairi, H Seto
Tetrahedron Letters 41 (18), 3395-3398, 2000
Crystal Structure of 1-Deoxy-D-xylulose 5-phosphate Reductoisomerase Complexed with Cofactors:-Implications of a Flexible Loop Movement upon Substrate Binding
S Yajima, T Nonaka, T Kuzuyama, H Seto, K Ohsawa
The Journal of Biochemistry 131 (3), 313-317, 2002
The A-factor-binding protein of Streptomyces griseus negatively controls streptomycin production and sporulation
K Miyake, T Kuzuyama, S Horinouchi, T Beppu
Journal of Bacteriology 172 (6), 3003-3008, 1990
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